[HTML][HTML] Bringing order to the glutamate chaos in schizophrenia
B Moghaddam - Neuron, 2003 - cell.com
Neuron, 2003•cell.com
Recent genetic linkage studies complement the existing evidence that implicates
abnormalities in NMDA receptor-mediated neurotransmission in the pathophysiology of
schizophrenia. At the same time, advances in our understanding of the complex
mechanisms that modulate the function of NMDA receptors suggest several novel sites for
pharmacological manipulation of these receptors. This presents exciting opportunities for
rational rather than serendipitous discovery of therapeutics for schizophrenia.
abnormalities in NMDA receptor-mediated neurotransmission in the pathophysiology of
schizophrenia. At the same time, advances in our understanding of the complex
mechanisms that modulate the function of NMDA receptors suggest several novel sites for
pharmacological manipulation of these receptors. This presents exciting opportunities for
rational rather than serendipitous discovery of therapeutics for schizophrenia.
Abstract
Recent genetic linkage studies complement the existing evidence that implicates abnormalities in NMDA receptor-mediated neurotransmission in the pathophysiology of schizophrenia. At the same time, advances in our understanding of the complex mechanisms that modulate the function of NMDA receptors suggest several novel sites for pharmacological manipulation of these receptors. This presents exciting opportunities for rational rather than serendipitous discovery of therapeutics for schizophrenia.
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