Hippocampal dysfunction in schizophrenia

NA Schmajuk - Hippocampus, 2001 - Wiley Online Library
NA Schmajuk
Hippocampus, 2001Wiley Online Library
Although not necessarily primary to the disease, hippocampal dysfunction in schizophrenia
is suggested by morphological changes in the hippocampal formation reported in
schizophrenic patients. This notion receives additional support from studies showing that 1)
similar behavioral deficits are exhibited by both schizophrenics and animals with
hippocampal lesions, and 2) some of these behavioral deficits are reversed by neuroleptics
in both schizophrenics and lesioned animals. A brain‐mapped neural network model is …
Abstract
Although not necessarily primary to the disease, hippocampal dysfunction in schizophrenia is suggested by morphological changes in the hippocampal formation reported in schizophrenic patients. This notion receives additional support from studies showing that 1) similar behavioral deficits are exhibited by both schizophrenics and animals with hippocampal lesions, and 2) some of these behavioral deficits are reversed by neuroleptics in both schizophrenics and lesioned animals. A brain‐mapped neural network model is used to explain how some impairments in attention can be caused by hippocampal dysfunction and ameliorated by dopaminergic blockers. Hippocampus 2001;11:599–613. © 2001 Wiley‐Liss, Inc.
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