[HTML][HTML] Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes
K Mahadev, X Wu, A Zilbering, L Zhu… - Journal of Biological …, 2001 - ASBMB
In a variety of cell types, insulin stimulation elicits the rapid production of H 2 O 2, which
causes the oxidative inhibition of protein-tyrosine phosphatases and enhances the tyrosine
phosphorylation of proteins in the early insulin action cascade (Mahadev, K., Zilbering, A.,
Zhu, L., and Goldstein, BJ (2001) J. Biol. Chem. 276, 21938–21942). In the present work, we
explored the potential role of insulin-induced H 2 O 2 generation on downstream insulin
signaling using diphenyleneiodonium (DPI), an inhibitor of cellular NADPH oxidase that …
causes the oxidative inhibition of protein-tyrosine phosphatases and enhances the tyrosine
phosphorylation of proteins in the early insulin action cascade (Mahadev, K., Zilbering, A.,
Zhu, L., and Goldstein, BJ (2001) J. Biol. Chem. 276, 21938–21942). In the present work, we
explored the potential role of insulin-induced H 2 O 2 generation on downstream insulin
signaling using diphenyleneiodonium (DPI), an inhibitor of cellular NADPH oxidase that …