Dietary fish oils inhibited secretion and stimulated intracellular degradation of apolipoprotein
(apo) B in hamster hepatocytes, while dietary sunflower oils stimulated secretion and had no
effect on degradation of apoB. To investigate the intracellular site at which fish oils act, we
have made use of our previous observations that inhibition of degradation by N-acetyl-leucyl-
leucyl-norleucinal (ALLN) results in accumulation of apoB in the trans-Golgi membrane and
does not stimulate secretion, while inhibition of degradation by o-phenanthroline results in …