[HTML][HTML] Oleate and Other Long Chain Fatty Acids Stimulate Low Density Lipoprotein Receptor Activity by Enhancing Acyl Coenzyme A: Cholesterol Acyltransferase …
SC Rumsey, NF Galeano, L Lipschitz… - Journal of Biological …, 1995 - ASBMB
Modification of dietary fatty acid composition results in changes in plasma cholesterol levels
in man. We examined the effect of in vitro fatty acid supplementation on low density
lipoprotein (LDL) receptor activity in cultured cells and questioned whether changes were
related to fatty acid-induced alterations in acyl-CoA: cholesterol acyltransferase (ACAT)
activity. Preincubation of cultured cells (ie human skin fibroblasts, J774 macrophages, and
HepG2 cells) with oleic acid (oleic acid: bovine serum albumin molar ratio 2: 1) at 37° C for …
in man. We examined the effect of in vitro fatty acid supplementation on low density
lipoprotein (LDL) receptor activity in cultured cells and questioned whether changes were
related to fatty acid-induced alterations in acyl-CoA: cholesterol acyltransferase (ACAT)
activity. Preincubation of cultured cells (ie human skin fibroblasts, J774 macrophages, and
HepG2 cells) with oleic acid (oleic acid: bovine serum albumin molar ratio 2: 1) at 37° C for …