[HTML][HTML] The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis* 210
The antibacterial and antifungal peptide hepcidin (LEAP-1) is expressed in the liver. This
circulating peptide has recently been found to also act as a signaling molecule in iron
metabolism. As such, it plays an important role in hereditary hemochromatosis, a serious
iron overload disease. In this study, we report the solution structures of the hepcidin-20 and-
25 amino acid peptides determined by standard two-dimensional 1 H NMR spectroscopy.
These small cysteine-rich peptides form a distorted β-sheet with an unusual vicinal disulfide …
circulating peptide has recently been found to also act as a signaling molecule in iron
metabolism. As such, it plays an important role in hereditary hemochromatosis, a serious
iron overload disease. In this study, we report the solution structures of the hepcidin-20 and-
25 amino acid peptides determined by standard two-dimensional 1 H NMR spectroscopy.
These small cysteine-rich peptides form a distorted β-sheet with an unusual vicinal disulfide …