[HTML][HTML] Synaptotagmin-1 is required for fibroblast growth factor-1 release
TM LaVallee, F Tarantini, S Gamble… - Journal of Biological …, 1998 - ASBMB
By using p65 synaptotagmin-1 and fibroblast growth factor (FGF)-1: β-galactosidase (β-gal)
NIH 3T3 cell co-transfectants, we demonstrate that a proteolytic fragment consisting of the
extravesicular domain of synaptotagmin-1 is released into the extracellular compartment in
response to temperature stress with similar kinetics and pharmacological properties as FGF-
1: β-gal. Using a deletion mutant that lacks 95 amino acids from the extravesicular domain of
synaptotagmin-1, neither synaptotagmin-1 nor FGF-1: β-gal are able to access the stress …
NIH 3T3 cell co-transfectants, we demonstrate that a proteolytic fragment consisting of the
extravesicular domain of synaptotagmin-1 is released into the extracellular compartment in
response to temperature stress with similar kinetics and pharmacological properties as FGF-
1: β-gal. Using a deletion mutant that lacks 95 amino acids from the extravesicular domain of
synaptotagmin-1, neither synaptotagmin-1 nor FGF-1: β-gal are able to access the stress …