Immunohistochemical localization of galectin-3 in malignant and benign human thyroid tissue.
D Cvejic, S Savin, I Paunovic, S Tatic… - Anticancer …, 1998 - europepmc.org
D Cvejic, S Savin, I Paunovic, S Tatic, M Havelka, J Sinadinovic
Anticancer research, 1998•europepmc.orgBackground Galectin-3 is an endogenous beta-galactoside binding lectin with putative roles
in development, immunomodulation, transformation and metastasis. The purpose of this
study was to analyze galectin-3 expression in a series of human thyroid neoplastic lesions.
Methods A total of 76 cases, including 47 specimens of thyroid malignancies, 14 follicular
adenomas and 15 specimens of normal thyroid tissue, were analyzed
immunohistochemically using a monoclonal antibody to galectin-3 and avidin-biotin …
in development, immunomodulation, transformation and metastasis. The purpose of this
study was to analyze galectin-3 expression in a series of human thyroid neoplastic lesions.
Methods A total of 76 cases, including 47 specimens of thyroid malignancies, 14 follicular
adenomas and 15 specimens of normal thyroid tissue, were analyzed
immunohistochemically using a monoclonal antibody to galectin-3 and avidin-biotin …
Background
Galectin-3 is an endogenous beta-galactoside binding lectin with putative roles in development, immunomodulation, transformation and metastasis. The purpose of this study was to analyze galectin-3 expression in a series of human thyroid neoplastic lesions.
Methods
A total of 76 cases, including 47 specimens of thyroid malignancies, 14 follicular adenomas and 15 specimens of normal thyroid tissue, were analyzed immunohistochemically using a monoclonal antibody to galectin-3 and avidin-biotin-peroxidase complex (ABC) method.
Results
The immunohistochemical staining results showed galectin-3 expression in neoplastic cells of all 20 cases of papillary carcinoma, 11 out of 15 follicular carcinomas, both oxyphilic carcinomas, all 10 anaplastic carcinomas and 5 out of 14 follicular adenomas. Galectin-3 localization was mostly cytoplasmic, but also membraneous or nuclear in some cells. Follicular cells in normal thyroid tissue were negative.
Conclusions
The results of this study indicate that galectin-3 gene is expressed at the protein level in most thyroid carcinomas and some adenomas. Galectin-3 expression was not clearly correlated with histopathological aggressiveness, dedifferentiation state or determination of malignancy of the follicular tumour. The role of galectin-3 in thyroid tumour biology remains to be elucidated.
europepmc.org