Gene expression profiles in normal and cancer cells

L Zhang, W Zhou, VE Velculescu, SE Kern, RH Hruban… - Science, 1997 - science.org
Science, 1997science.org
As a step toward understanding the complex differences between normal and cancer cells in
humans, gene expression patterns were examined in gastrointestinal tumors. More than
300,000 transcripts derived from at least 45,000 different genes were analyzed. Although
extensive similarity was noted between the expression profiles, more than 500 transcripts
that were expressed at significantly different levels in normal and neoplastic cells were
identified. These data provide insight into the extent of expression differences underlying …
As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers.
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