PAX8-PPARγ rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses
MN Nikiforova, PW Biddinger, CM Caudill… - The American journal …, 2002 - journals.lww.com
Abstract A PAX8-PPARγ rearrangement has been recently identified in follicular thyroid
carcinomas, but not in follicular adenomas or other thyroid tumors. We report here the
analyses of PAX8-PPARγ in a series of 118 thyroid tumors using a newly developed RT-
PCR assay to detect this rearrangement in frozen and paraffin-embedded tissues and using
immunostaining with a PPARγ antibody. PAX8-PPARγ was detected by RT-PCR in eight of
15 (53%) follicular carcinomas and two of 25 (8%) follicular adenomas but not in 35 papillary …
carcinomas, but not in follicular adenomas or other thyroid tumors. We report here the
analyses of PAX8-PPARγ in a series of 118 thyroid tumors using a newly developed RT-
PCR assay to detect this rearrangement in frozen and paraffin-embedded tissues and using
immunostaining with a PPARγ antibody. PAX8-PPARγ was detected by RT-PCR in eight of
15 (53%) follicular carcinomas and two of 25 (8%) follicular adenomas but not in 35 papillary …