A substrain of NZB mouse as an animal model of autoimmune inner ear disease
M Sone, H Nariuchi, K Saito, N Yanagita - Hearing research, 1995 - Elsevier
A substrain of an autoimmune-prone mouse, NZB/kl, was found to show spontaneous
elevation of the auditory brainstem response (ABR) threshold with age. Morphological
examination of the inner ear in NZB/kl mice with high ABR thresholds revealed pathological
changes confined to the stria vascularis, including marked thickening of the capillary
basement membrane which contained many foamy structures, and vacuolar degeneration of
the intermediate cells. Circular or granular IgM deposits and some IgG deposits were found …
elevation of the auditory brainstem response (ABR) threshold with age. Morphological
examination of the inner ear in NZB/kl mice with high ABR thresholds revealed pathological
changes confined to the stria vascularis, including marked thickening of the capillary
basement membrane which contained many foamy structures, and vacuolar degeneration of
the intermediate cells. Circular or granular IgM deposits and some IgG deposits were found …