Sequence 104–117 of myelin proteolipid protein is a cryptic encephalitogenic T cell determinant for SJL/J mice

VK Tuohy, DM Thomas - Journal of neuroimmunology, 1995 - Elsevier
Immunization of animals with myelin proteolipid protein (PLP) causes experimental
autoimmune encephalomyelitis (EAE), a disease model that shares many features with
human multiple sclerosis (MS). The SJL/J (H-25) mouse is widely used in EAE studies
because of its high disease susceptibility. Previous studies have shown that sequences 139–
151 HCLGKWLGHPDKF and 178–191 NTWTTCQSIAFPSK represent distinct co-
immunodominant encephalitogenic determinants of PLP for SJL/J mice. In the present study …