Interferon-γ production to inner ear antigens by T cells from patients with autoimmune sensorineural hearing loss

RR Lorenz, CA Solares, P Williams, J Sikora… - Journal of …, 2002 - Elsevier
Autoimmune sensorineural hearing loss (ASNHL) typically produces bilateral rapidly
progressive loss of hearing over a few days or weeks, but may also produce sudden loss
over a few hours. The diagnosis is made by excluding ototoxicity, systemic disease, and
other factors that mimic ASNHL and by showing a therapeutic response to corticosteroid
treatment. Antibody production and T-cell proliferative responses to inner ear antigens have
been implicated in the etiopathogenesis of ASNHL. In the current study, we have extended …