The enzymatic inactivation of the fatty acid amide class of signaling lipids
BF Cravatt, AH Lichtman - Chemistry and physics of lipids, 2002 - Elsevier
The fatty acid amide (FAA) class of signaling lipids modulates a number of neurobehavioral
processes in mammals, including pain, sleep, feeding, and locomotor activity.
Representative FAAs include the endogenous cannabinoid anandamide and the sleep-
inducing lipid oleamide. Despite activating several neuroreceptor systems in vitro, most
FAAs produce only weak and transient behavioral effects in vivo, presumably due to their
expeditious catabolism. This review focuses on one enzyme, fatty acid amide hydrolase …
processes in mammals, including pain, sleep, feeding, and locomotor activity.
Representative FAAs include the endogenous cannabinoid anandamide and the sleep-
inducing lipid oleamide. Despite activating several neuroreceptor systems in vitro, most
FAAs produce only weak and transient behavioral effects in vivo, presumably due to their
expeditious catabolism. This review focuses on one enzyme, fatty acid amide hydrolase …