Immunoglobulin VH gene expression in human aging
X Wang, BD Stollar - Clinical immunology, 1999 - Elsevier
Immune responses change in aging humans, but it is not known whether there is an age-
associated change in the expressed B cell repertoire. We compared Ig VH cDNA libraries
from circulating B cells of five elderly and three young human adults. As in young persons,
nearly two-thirds of the cDNA clones from older subjects had zero to three VH mutations,
although there was more individual variation among the elderly. VH4 family expression
increased in older subjects, both in unmutated and in mutated cDNA clones, whereas VH3 …
associated change in the expressed B cell repertoire. We compared Ig VH cDNA libraries
from circulating B cells of five elderly and three young human adults. As in young persons,
nearly two-thirds of the cDNA clones from older subjects had zero to three VH mutations,
although there was more individual variation among the elderly. VH4 family expression
increased in older subjects, both in unmutated and in mutated cDNA clones, whereas VH3 …