Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice.

CM Allan, JM Taylor - Journal of lipid research, 1996 - ASBMB
The human apolipoprotein (apo) C-IV gene has been recently identified: it is closely linked
to the promoter region of the apoC-II gene (Allan, CM, D. Walker, J. Segrest, and JM Taylor.
1995. Genomics. 28: 291-300). To determine the effect of apoC-IV gene expression on
lipoprotein metabolism, transgenic mice were generated using a human apoC-IV cDNA
construct. Human apoC-IV was found associated with plasma lipoproteins (d< 1.21 g/ml),
mainly in very low density lipoproteins (VLDL), and higher molecular mass isoforms were …