[HTML][HTML] Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role …
Y Suzaki, M Yoshizumi, S Kagami, AH Koyama… - Journal of Biological …, 2002 - ASBMB
Reactive oxygen species, generated by reduction-oxidation (redox) reactions, have been
recognized as one of the major mediators of ischemia and reperfusion injury in the brain.
Reactive oxygen species-induced cerebral events are attributable, in part, to the change in
intracellular signaling molecules including mitogen-activated protein (MAP) kinases. Big
MAP kinase 1 (BMK1), also known as ERK5, is a newly identified member of the MAP kinase
family and has been reported to be sensitive to oxidative stress. In the present study, we …
recognized as one of the major mediators of ischemia and reperfusion injury in the brain.
Reactive oxygen species-induced cerebral events are attributable, in part, to the change in
intracellular signaling molecules including mitogen-activated protein (MAP) kinases. Big
MAP kinase 1 (BMK1), also known as ERK5, is a newly identified member of the MAP kinase
family and has been reported to be sensitive to oxidative stress. In the present study, we …