Whereas local microglial cells of the CNS rapidly respond to injury, little is known about the
functional role of resident macrophages of the peripheral nervous system in nerve
pathology. Using bone marrow chimeric rats, we recently identified individual resident
endoneurial macrophages that rapidly became activated after nerve injury. However, the
extent of local macrophage activation and its quantitative contribution to the total
macrophage response is unknown. We now have created chimeric mice by transplanting …