[HTML][HTML] Yellow fever vector live-virus vaccines: West Nile virus vaccine development

J Arroyo, CA Miller, J Catalan, TP Monath - Trends in molecular medicine, 2001 - cell.com
J Arroyo, CA Miller, J Catalan, TP Monath
Trends in molecular medicine, 2001cell.com
By combining molecular-biological techniques with our increased understanding of the
effect of gene sequence modification on viral function, yellow fever 17D, a positive-strand
RNA virus vaccine, has been manipulated to induce a protective immune response against
viruses of the same family (eg Japanese encephalitis and dengue viruses). Triggered by the
emergence of West Nile virus infections in the New World afflicting humans, horses and
birds, the success of this recombinant technology has prompted the rapid development of a …
Abstract
By combining molecular-biological techniques with our increased understanding of the effect of gene sequence modification on viral function, yellow fever 17D, a positive-strand RNA virus vaccine, has been manipulated to induce a protective immune response against viruses of the same family (e.g. Japanese encephalitis and dengue viruses). Triggered by the emergence of West Nile virus infections in the New World afflicting humans, horses and birds, the success of this recombinant technology has prompted the rapid development of a live-virus attenuated candidate vaccine against West Nile virus.
cell.com