Killing of Borrelia burgdorferi by macrophages is dependent on oxygen radicals and nitric oxide and can be enhanced by antibodies to outer surface proteins of the …
M Modolell, UE Schaible, M Rittig, MM Simon - Immunology letters, 1994 - Elsevier
Interaction of B. burgdorferi organisms with mouse bone marrow-derived macrophages
(BMMΦ) leads to phagocytosis of microorganisms, induction of nitric oxide (NO) and
superoxide radicals (O 2− by BMMΦ and killing of spirochetes. Destruction of spirochetes by
BMMΦ was quantified by a new method based on the release of radioactivity from
spirochetes pre-labelled with [3 H] adenine. Uptake of B. burgdorferi by BMMΦ, which
mainly occurs by coiling phagocytosis, generation of NO and O 2− radicals as well as killing …
(BMMΦ) leads to phagocytosis of microorganisms, induction of nitric oxide (NO) and
superoxide radicals (O 2− by BMMΦ and killing of spirochetes. Destruction of spirochetes by
BMMΦ was quantified by a new method based on the release of radioactivity from
spirochetes pre-labelled with [3 H] adenine. Uptake of B. burgdorferi by BMMΦ, which
mainly occurs by coiling phagocytosis, generation of NO and O 2− radicals as well as killing …