Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-life
WM Watkins, M Mosobo - Transactions of the Royal Society of Tropical …, 1993 - Elsevier
In an area of continuing transmission of Plasmodium falciparum on the Kenya coast,
children treated with pyrimethamine-sulfadoxine experienced rapid parasite clearance,
although a high proportion became reinfected within a short time. The frequency of
pyrimethamine resistance in vitro in new infections was higher during the elimination phase
of drug from a previous treatment. In infections which occurred at times when predicted
residual drug concentrations were no longer inhibitory, incidence of pyrimethamine …
children treated with pyrimethamine-sulfadoxine experienced rapid parasite clearance,
although a high proportion became reinfected within a short time. The frequency of
pyrimethamine resistance in vitro in new infections was higher during the elimination phase
of drug from a previous treatment. In infections which occurred at times when predicted
residual drug concentrations were no longer inhibitory, incidence of pyrimethamine …