[HTML][HTML] sgk is an aldosterone-induced kinase in the renal collecting duct: effects on epithelial Na+ channels
A Náray-Fejes-Tóth, C Canessa, ES Cleaveland… - Journal of Biological …, 1999 - ASBMB
The early phase of the stimulatory effect of aldosterone on sodium reabsorption in renal
epithelia is thought to involve activation of apical sodium channels. However, the genes
initiating this effect are unknown. We used a combination of polymerase chain reaction-
based subtractive hybridization and differential display techniques to identify aldosterone-
regulated immediate early genes in renal mineralocorticoid target cells. We report here that
aldosterone rapidly increases mRNA levels of a putative Ser/Thr kinase, sgk (or serum …
epithelia is thought to involve activation of apical sodium channels. However, the genes
initiating this effect are unknown. We used a combination of polymerase chain reaction-
based subtractive hybridization and differential display techniques to identify aldosterone-
regulated immediate early genes in renal mineralocorticoid target cells. We report here that
aldosterone rapidly increases mRNA levels of a putative Ser/Thr kinase, sgk (or serum …