[HTML][HTML] p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets: evidence that proline-directed …
RM Kramer, EF Roberts, SL Um… - Journal of Biological …, 1996 - ASBMB
The Ca 2+-sensitive 85-kDa cytosolic phospholipase A 2 (cPLA 2) is responsible for
thrombin-stimulated mobilization of arachidonic acid for the synthesis of thromboxane A 2 in
human platelets. We have previously shown that thrombin activates p38 kinase, a recently
discovered new member of the mitogen-activated protein kinase family (Kramer, RM,
Roberts, EF, Strifler, BA, and Johnstone, EM (1995) J. Biol. Chem. 270, 27395-27398) and
also induces phosphorylation of cPLA 2, thereby increasing its intrinsic catalytic activity. In …
thrombin-stimulated mobilization of arachidonic acid for the synthesis of thromboxane A 2 in
human platelets. We have previously shown that thrombin activates p38 kinase, a recently
discovered new member of the mitogen-activated protein kinase family (Kramer, RM,
Roberts, EF, Strifler, BA, and Johnstone, EM (1995) J. Biol. Chem. 270, 27395-27398) and
also induces phosphorylation of cPLA 2, thereby increasing its intrinsic catalytic activity. In …