[HTML][HTML] Stimulation of a vascular smooth muscle cell NAD (P) H oxidase by thrombin: evidence that p47phox may participate in forming this oxidase in vitro and in vivo
C Patterson, J Ruef, NR Madamanchi… - Journal of Biological …, 1999 - ASBMB
Thrombin is a potent vascular smooth muscle cell (VSMC) mitogen. Because recent
evidence implicates reactive oxygen intermediates (ROI) in VSMC proliferation in general
and atherogenesis in particular, we investigated whether ROI generation is necessary for
thrombin-induced mitogenesis. Treatment of human aortic smooth muscle cells with
thrombin increased DNA synthesis, an effect that was antagonized by diphenyleneiodonium
but not by other inhibitors of cellular oxidase systems. This effect of thrombin was …
evidence implicates reactive oxygen intermediates (ROI) in VSMC proliferation in general
and atherogenesis in particular, we investigated whether ROI generation is necessary for
thrombin-induced mitogenesis. Treatment of human aortic smooth muscle cells with
thrombin increased DNA synthesis, an effect that was antagonized by diphenyleneiodonium
but not by other inhibitors of cellular oxidase systems. This effect of thrombin was …