[HTML][HTML] Tumor necrosis factor-α generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade
CH Woo, YW Eom, MH Yoo, HJ You, HJ Han… - Journal of Biological …, 2000 - ASBMB
Reactive oxygen species (ROS) are important regulatory molecules implicated in the
signaling cascade triggered by tumor necrosis factor (TNF)-α, although the events through
which TNF-α induces ROS generation are not yet well characterized. We therefore
investigated selected candidates likely to mediate TNF-α-induced ROS generation.
Consistent with the role of Rac in that process, stable expression of Rac Asn-17, a dominant
negative Rac1 mutant, completely blocked TNF-α-induced ROS generation. To understand …
signaling cascade triggered by tumor necrosis factor (TNF)-α, although the events through
which TNF-α induces ROS generation are not yet well characterized. We therefore
investigated selected candidates likely to mediate TNF-α-induced ROS generation.
Consistent with the role of Rac in that process, stable expression of Rac Asn-17, a dominant
negative Rac1 mutant, completely blocked TNF-α-induced ROS generation. To understand …