Involvement of NADH/NADPH oxidase in human platelet ROS production

T Seno, N Inoue, D Gao, M Okuda, Y Sumi, K Matsui… - Thrombosis research, 2001 - Elsevier
Platelets play an important role in atherosclerotic and thromboembolic vascular diseases. It
has been reported that reactive oxygen species (ROS) could modify platelet function, and
platelets themselves have the ability to produce ROS. However, the enzymatic sources of
ROS in platelets have not been fully determined. The NADH/NADPH oxidase system was
originally identified as the major source of ROS in phagocytes. Recently, it has become
evident that this oxidase is functionally expressed not only in phagocytes but also in various …