[HTML][HTML] Phoxy lipids: revealing PX domains as phosphoinositide binding modules
MJ Wishart, GS Taylor, JE Dixon - Cell, 2001 - cell.com
MJ Wishart, GS Taylor, JE Dixon
Cell, 2001•cell.comThe coordination of cellular signaling events requires both spatial and temporal regulation.
A recurring theme among eukaryotic organisms is the use of phosphoinositide-specific
binding domains to direct proteins to discrete sites within cells where their function (s) are
required. To date, a number of distinct, highly conserved phosphoinositide binding motifs
have been identified, the most well-characterized of which include the C2 (PKC conserved
region 2), ENTH (epsin N-terminal homology)(
A recurring theme among eukaryotic organisms is the use of phosphoinositide-specific
binding domains to direct proteins to discrete sites within cells where their function (s) are
required. To date, a number of distinct, highly conserved phosphoinositide binding motifs
have been identified, the most well-characterized of which include the C2 (PKC conserved
region 2), ENTH (epsin N-terminal homology)(
The coordination of cellular signaling events requires both spatial and temporal regulation. A recurring theme among eukaryotic organisms is the use of phosphoinositide-specific binding domains to direct proteins to discrete sites within cells where their function (s) are required. To date, a number of distinct, highly conserved phosphoinositide binding motifs have been identified, the most well-characterized of which include the C2 (PKC conserved region 2), ENTH (epsin N-terminal homology)(
cell.com