Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic …
BA Stoica, VA Movsesyan, PM Lea Iv… - Molecular and Cellular …, 2003 - Elsevier
Neuronal apoptosis has been implicated as an important mechanism of cell death in acute
and chronic neurodegenerative disorders. Ceramide is a product of sphingolipid metabolism
which induces neuronal apoptosis in culture, and ceramide levels increase in neurons
during various conditions associated with cell death. In this study we investigate the
mechanism of ceramide-induced apoptosis in primary cortical neuronal cells. We show that
ceramide treatment initiates a cascade of biochemical alterations associated with cell death …
and chronic neurodegenerative disorders. Ceramide is a product of sphingolipid metabolism
which induces neuronal apoptosis in culture, and ceramide levels increase in neurons
during various conditions associated with cell death. In this study we investigate the
mechanism of ceramide-induced apoptosis in primary cortical neuronal cells. We show that
ceramide treatment initiates a cascade of biochemical alterations associated with cell death …