Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits
R Kotloski, M Lynch, S Lauersdorf, T Sutula - Progress in brain research, 2002 - Elsevier
The long-term effects of repeated brief seizures on spatial memory and hippocampal
neuronal populations were assessed in kindled rats. Rats that experienced a range of 3
afterdischarges to 134 secondary generalized tonic-clonic (Class V) seizures evoked by
stimulation of the olfactory bulb were evaluated in a radial arm maze task that is a measure
of spatial memory and is disrupted by hippocampal damage. After completion of the memory
task and a minimum of∼ 3 months after the last evoked seizure, stereological methods were …
neuronal populations were assessed in kindled rats. Rats that experienced a range of 3
afterdischarges to 134 secondary generalized tonic-clonic (Class V) seizures evoked by
stimulation of the olfactory bulb were evaluated in a radial arm maze task that is a measure
of spatial memory and is disrupted by hippocampal damage. After completion of the memory
task and a minimum of∼ 3 months after the last evoked seizure, stereological methods were …