Lymphangiogenesis and cancer metastasis
SA Stacker, MG Achen, L Jussila, ME Baldwin… - Nature Reviews …, 2002 - nature.com
SA Stacker, MG Achen, L Jussila, ME Baldwin, K Alitalo
Nature Reviews Cancer, 2002•nature.comLymphatic vessels are important for the spread of solid tumours, but the mechanisms that
underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in
tumour metastasis has been less clear. This article reviews recent experimental and clinico-
pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours
are associated with an enhanced metastatic process.
underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in
tumour metastasis has been less clear. This article reviews recent experimental and clinico-
pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours
are associated with an enhanced metastatic process.
Abstract
Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear. This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours are associated with an enhanced metastatic process.
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