It is widely accepted that blood coagulation in vivo is initiated during normal hemostasis, as
well as during intravascular thrombus formation, when the cell-surface protein, tissue factor
(TF), is exposed to the blood as a consequence of vascular injury. In addition to its essential
role in hemostasis, tissue factor may be also implicated in several pathophysiological
processes, such as intracellular signaling, cell proliferation, and inflammation. For these
reasons, the tissue factor: factor VIIa complex has been the subject of intense research …