The interleukin 2 receptor
KA Smith - Annual review of cell biology, 1989 - annualreviews.org
Annual review of cell biology, 1989•annualreviews.org
The idea that immune responsiveness and immune memory are determined by
lymphocytotrophic hormones (interleukins) was first introduced when the T cell growth factor,
interleukin 2 (IL-2), was found to bind with high affinity to sites expressed only on antigen-or
lectin-activated T lymphocytes (Robb et al 1981) _ However, inherent in the concept that the
immune system is controlled in a fashion similar to other organ systems is the necessity to
demonstrate that the interleukins and their receptors actually express all of the …
lymphocytotrophic hormones (interleukins) was first introduced when the T cell growth factor,
interleukin 2 (IL-2), was found to bind with high affinity to sites expressed only on antigen-or
lectin-activated T lymphocytes (Robb et al 1981) _ However, inherent in the concept that the
immune system is controlled in a fashion similar to other organ systems is the necessity to
demonstrate that the interleukins and their receptors actually express all of the …
The idea that immune responsiveness and immune memory are determined by lymphocytotrophic hormones (interleukins) was first introduced when the T cell growth factor, interleukin 2 (IL-2), was found to bind with high affinity to sites expressed only on antigen-or lectin-activated T lymphocytes (Robb et al 1981) _ However, inherent in the concept that the immune system is controlled in a fashion similar to other organ systems is the necessity to demonstrate that the interleukins and their receptors actually express all of the characteristics of the more classical hormone-receptor systems. This review will focus on this point and illustrate how the T cell IL-2-receptor system is now the system of choice for fundamental studies
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