KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer
Science, 2001•science.org
Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we
show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-
heterozygosity analysis revealed that one KLF6 allele is deleted in 77%(17 of 22) of primary
prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71%
of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21
(WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation …
show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-
heterozygosity analysis revealed that one KLF6 allele is deleted in 77%(17 of 22) of primary
prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71%
of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21
(WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation …
Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that theKLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest thatKLF6 is a tumor suppressor gene involved in human prostate cancer.
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