PAC1 receptor-mediated relaxation of longitudinal muscle of the mouse proximal colon
K Mukai, Y Satoh, A Fujita, H Hashimoto, A Baba… - Japanese journal of …, 2002 - Elsevier
K Mukai, Y Satoh, A Fujita, H Hashimoto, A Baba, F Hata
Japanese journal of pharmacology, 2002•ElsevierSince pituitary adenylate cyclase-activating polypeptide (PACAP) was shown to partially
mediate nonadrenergic, noncholinergic (NANC) relaxation of longitudinal muscle of the
proximal colon of ICR mice, we further studied the receptor subtype activated by PACAP by
using a mutant mouse whose PAC1 receptors are markedly reduced. In wild-type mice, the
PACAP-mediated component of NANC relaxation was 33%, but it was absent in the mutant
mice. The potency of exogenous PACAP in inducing relaxation in the mutant mice was one …
mediate nonadrenergic, noncholinergic (NANC) relaxation of longitudinal muscle of the
proximal colon of ICR mice, we further studied the receptor subtype activated by PACAP by
using a mutant mouse whose PAC1 receptors are markedly reduced. In wild-type mice, the
PACAP-mediated component of NANC relaxation was 33%, but it was absent in the mutant
mice. The potency of exogenous PACAP in inducing relaxation in the mutant mice was one …
Abstract
Since pituitary adenylate cyclase-activating polypeptide (PACAP) was shown to partially mediate nonadrenergic, noncholinergic (NANC) relaxation of longitudinal muscle of the proximal colon of ICR mice, we further studied the receptor subtype activated by PACAP by using a mutant mouse whose PAC1 receptors are markedly reduced. In wild-type mice, the PACAP-mediated component of NANC relaxation was 33%, but it was absent in the mutant mice. The potency of exogenous PACAP in inducing relaxation in the mutant mice was one hundredth of that in wild-type mice. VPAC1 and VPAC2 receptors were not suggested to have any role in the relaxation. These results suggest that PACAP mediates NANC relaxation of longitudinal muscle of mouse proximal colon via PAC1 receptors.
Elsevier
