Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on gonadotropin-releasing hormone and somatostatin gene expression in the rat brain
S Li, V Grinevich, A Fournier, G Pelletier - Molecular brain research, 1996 - Elsevier
Pituitary adenylate cyclase-activating peptide (PACAP) is a 38-amino acid polypeptide, first
isolated from ovine hypothalamus, which directly stimulates the release of several pituitary
hormones, including GH, ACTH, and LH. The presence of PACAP receptors in several brain
areas, including the hypothalamus, suggests that this peptide might play a role as
neurotransmitter/neuromodulator. We have thus investigated the effects of
intracerebroventricular (icv) and intravenous (iv) injections of PACAP and the potent PACAP …
isolated from ovine hypothalamus, which directly stimulates the release of several pituitary
hormones, including GH, ACTH, and LH. The presence of PACAP receptors in several brain
areas, including the hypothalamus, suggests that this peptide might play a role as
neurotransmitter/neuromodulator. We have thus investigated the effects of
intracerebroventricular (icv) and intravenous (iv) injections of PACAP and the potent PACAP …