Regulation of ceramide production and apoptosis
RN Kolesnick, M Krönke - Annual review of physiology, 1998 - annualreviews.org
RN Kolesnick, M Krönke
Annual review of physiology, 1998•annualreviews.org▪ Abstract Ceramide is a sphingosine-based lipid signaling molecule that regulates cellular
differentiation, proliferation, and apoptosis. The emerging picture suggests that coupling of
ceramide to specific signaling cascades is both stimulus and cell-type specific. Ceramide
action is determined within the context of other stimuli and by the subcellular topology of its
production. Here, we discuss the pathways of ceramide generation and the interaction of
ceramide with caspases and other apoptotic signaling cascades.
differentiation, proliferation, and apoptosis. The emerging picture suggests that coupling of
ceramide to specific signaling cascades is both stimulus and cell-type specific. Ceramide
action is determined within the context of other stimuli and by the subcellular topology of its
production. Here, we discuss the pathways of ceramide generation and the interaction of
ceramide with caspases and other apoptotic signaling cascades.
▪ Abstract
Ceramide is a sphingosine-based lipid signaling molecule that regulates cellular differentiation, proliferation, and apoptosis. The emerging picture suggests that coupling of ceramide to specific signaling cascades is both stimulus and cell-type specific. Ceramide action is determined within the context of other stimuli and by the subcellular topology of its production. Here, we discuss the pathways of ceramide generation and the interaction of ceramide with caspases and other apoptotic signaling cascades.
Annual Reviews