The interaction of mitochondria with proapoptotic proteins activates apoptosis pathways.
Previous findings have identified ganglioside GD3 (GD3) as an emerging apoptotic lipid
intermediate that targets mitochondria in response to death signals. Using immunoelectron
and laser scanning confocal microscopy, we characterize the trafficking of GD3 to
mitochondria in response to tumor necrosis factor-α (TNF-α) in rat hepatocytes. In control
hepatocytes, GD3 is present predominantly at the plasma membrane as well as in the …