[HTML][HTML] TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase
R Schwandner, K Wiegmann, K Bernardo… - Journal of Biological …, 1998 - ASBMB
Sphingomyelinase (SMase) activation and ceramide generation have emerged as an
important signaling pathway transducing diverse biological effects of cytokine receptors like
p55 tumor necrosis factor (TNF) receptor or Fas. Here we describe the TNF-dependent
activation of acid SMase (A-SMase) through the p55 TNF receptor-associated proteins
TRADD and FADD. Overexpression of TRADD and FADD in 293 cells did not change basal
activity of A-SMase but enhanced TNF-induced stimulation of A-SMase. Other TNF R55 …
important signaling pathway transducing diverse biological effects of cytokine receptors like
p55 tumor necrosis factor (TNF) receptor or Fas. Here we describe the TNF-dependent
activation of acid SMase (A-SMase) through the p55 TNF receptor-associated proteins
TRADD and FADD. Overexpression of TRADD and FADD in 293 cells did not change basal
activity of A-SMase but enhanced TNF-induced stimulation of A-SMase. Other TNF R55 …