Short-chain ceramide regulates hepatic methionine adenosyltransferase expression

LM Frago, C Paņeda, I Fabregat, I Varela-Nieto - Journal of hepatology, 2001 - Elsevier
Background: The metabolism of methionine plays an important role in regulating hepatic
cellular function. Methionine adenosyltransferase (MAT) is the enzyme that catalyses the
biosynthesis of S-adenosylmethionine (AdoMet) from ATP and methionine. Liver-specific
MAT I/III levels are down-regulated in the regenerating rat liver after partial hepatectomy.
Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are two cytokines fundamental for
liver regeneration. TNF-α stimulates sphingomyelin metabolism and ceramide generation in …