S–Adenosylmethionine Treatment Prevents Carbon Tetrachloride—InducedS–Adenosylmethionine Synthetase Inactivation and Attenuates Liver Injury
F Corrales, A Giménez, L Alvarez, J Caballería… - Hepatology, 1992 - journals.lww.com
Administration of carbon tetrachloride to rats resulted in induction of hepatic fibrosis and a
60% reduction of hepatic S–adenosylmethionine synthetase activity without producing any
significant modification of hepatic levels of S–adenosylmethionine synthetase messenger
RNA. The reduction of S–adenosylmethionine synthetase activity was corrected by treatment
with S–adenosylmethionine (3 mg/kg/day, intramuscularly). Administration of carbon
tetrachloride also produced a 45% depletion of liver glutathione (reduced form) that was …
60% reduction of hepatic S–adenosylmethionine synthetase activity without producing any
significant modification of hepatic levels of S–adenosylmethionine synthetase messenger
RNA. The reduction of S–adenosylmethionine synthetase activity was corrected by treatment
with S–adenosylmethionine (3 mg/kg/day, intramuscularly). Administration of carbon
tetrachloride also produced a 45% depletion of liver glutathione (reduced form) that was …
