CXCR3 and CCR5 ligands in rheumatoid arthritis synovium
DD Patel, JP Zachariah, LP Whichard - Clinical immunology, 2001 - Elsevier
The pathogenesis of rheumatoid arthritis (RA) may be mediated by Th1-type T cells. Since
chemokine receptors CXCR3 and CCR5 are preferentially expressed on Th1 cells, we
tested the expression and regulation of several chemokines, including those that signal
through CXCR3 (interferon-γ-inducible protein of 10 kDa, IP-10, CXCL10; and monokine
induced by interferon-γ, Mig, CXCL9) and CCR5 (macrophage inflammatory protein (Mip)-
1α, CCL3; and Mip-1β, CCL4) in RA synovial fluids, synovial tissues, and blood. Synovial …
chemokine receptors CXCR3 and CCR5 are preferentially expressed on Th1 cells, we
tested the expression and regulation of several chemokines, including those that signal
through CXCR3 (interferon-γ-inducible protein of 10 kDa, IP-10, CXCL10; and monokine
induced by interferon-γ, Mig, CXCL9) and CCR5 (macrophage inflammatory protein (Mip)-
1α, CCL3; and Mip-1β, CCL4) in RA synovial fluids, synovial tissues, and blood. Synovial …