What can we learn about rheumatoid arthritis from animal models?
L Klareskog - Springer seminars in immunopathology, 1989 - Springer
Springer seminars in immunopathology, 1989•Springer
The use and choice of animal models in efforts to understand the pathogenesis of
rheumatoid arthritis (RA) as well as finding new pathways to counteract the disease are
dependent largely on which aspects of rheumatoid arthritis are in the focus of the
investigator. In this way, our increasing knowledge of the pathogenesis of RA should
obviously lead also to a more selective use of animal models to illuminate distinct features of
the rheumatoid disease. Conversely, it is feasible that the pathogenetic relevance of findings …
rheumatoid arthritis (RA) as well as finding new pathways to counteract the disease are
dependent largely on which aspects of rheumatoid arthritis are in the focus of the
investigator. In this way, our increasing knowledge of the pathogenesis of RA should
obviously lead also to a more selective use of animal models to illuminate distinct features of
the rheumatoid disease. Conversely, it is feasible that the pathogenetic relevance of findings …
The use and choice of animal models in efforts to understand the pathogenesis of rheumatoid arthritis (RA) as well as finding new pathways to counteract the disease are dependent largely on which aspects of rheumatoid arthritis are in the focus of the investigator. In this way, our increasing knowledge of the pathogenesis of RA should obviously lead also to a more selective use of animal models to illuminate distinct features of the rheumatoid disease. Conversely, it is feasible that the pathogenetic relevance of findings made in the human disease can ultimately only be tested by means of specific intervention with the human disease applying procedures that have previously been sufficiently refined in the animal system; thus a continuous two-way exchange of experience between human and animal systems will probably be of increasing importance as our means for specific intervention within the human and rodent immune systems develop.
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