[HTML][HTML] Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter

AN Hollenberg, VS Susulic, JP Madura, B Zhang… - Journal of Biological …, 1997 - ASBMB
The ob gene product, leptin, is a major hormonal regulator of appetite and fat cell mass.
Recent work has suggested that the antidiabetic agents, the thiazolidinediones (TZ), which
are also high affinity ligands of peroxisome proliferator-activated receptor-γ (PPARγ), inhibit
leptin expression in rodents. To examine the effects of this class of drug on the leptin gene in
adipocytes we performed Northern analysis on primary rat adipocytes cultured in the
presence or absence of TZ. TZ reduced leptin mRNA levels by 75%. To determine whether …