[HTML][HTML] Turnover of lymphocytes and conceptual paradigms in HIV infection

G Silvestri, MB Feinberg - The Journal of clinical …, 2003 - Am Soc Clin Investig
G Silvestri, MB Feinberg
The Journal of clinical investigation, 2003Am Soc Clin Investig
Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models
that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize
the pathogenic role of generalized immune system activation. The observation that
increases in T cell turnover seen in HIV-infected individuals primarily reflect increased
proliferation of effector-memory T cells supports the concept that chronic immune activation
plays a prominent, if not predominant, role in the pathogenesis of AIDS.
Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.
The Journal of Clinical Investigation