[HTML][HTML] Idiopathic IgA nephropathy

JL Rodicio - Kidney International, 1984 - Elsevier
JL Rodicio
Kidney International, 1984Elsevier
Discussion DR. JosE L. RoDiclo (Jefe del Servicio de Nefrologia, Ciudad Sanitaria de la
Seguirdad Social J0 de Octubre, Madrid, Spain): Before considering the manifestations of
this interesting condition and its features in the patient presented today, let us first define IgA
nephropathy and distinguish it from other renal diseases. Definition Berger and Hinglais first
characterized IgA nephropathy in 1968 [1], although Galle and Berger had described a
similar glomerular nephropathy with" intercapillary fibrinoid deposits" in 1962 [2], and Galle …
Discussion
DR. JosE L. RoDiclo (Jefe del Servicio de Nefrologia, Ciudad Sanitaria de la Seguirdad Social J0 de Octubre, Madrid, Spain): Before considering the manifestations of this interesting condition and its features in the patient presented today, let us first define IgA nephropathy and distinguish it from other renal diseases.
Definition Berger and Hinglais first characterized IgA nephropathy in 1968 [1], although Galle and Berger had described a similar glomerular nephropathy with" intercapillary fibrinoid deposits" in 1962 [2], and Galle had observed these deposits on electron microscopy in 1964 [3]. Idiopathic IgA nephropathy is characterized pathologically by the presence of diffuse, granular mesangial IgA deposits and, by definition, by the absence of any recognizable systemic disease. All the patients originally described by Berger with IgA mesangial glomerulonephritis or idiopathic IgA nephropathy had normal renal function, macroor microscopic hematuria, and proteinuria. Both the hematuria and proteinuria were exacerbated by upper respiratory tract infections [1, 4—6].
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