[HTML][HTML] Gradual adaptation of HIV to human host populations: good or bad news?
C Brander, BD Walker - Nature medicine, 2003 - nature.com
C Brander, BD Walker
Nature medicine, 2003•nature.comThe continuous evolution and adaptation of HIV to its host has produced extensive global
viral diversity. Understanding the kinetics and directions of this continuing adaptation and its
impact on viral fitness, immunogenicity and pathogenicity will be crucial to the successful
design of effective HIV vaccines. Here we discuss some potential scenarios of viral and host
coevolution.
viral diversity. Understanding the kinetics and directions of this continuing adaptation and its
impact on viral fitness, immunogenicity and pathogenicity will be crucial to the successful
design of effective HIV vaccines. Here we discuss some potential scenarios of viral and host
coevolution.
Abstract
The continuous evolution and adaptation of HIV to its host has produced extensive global viral diversity. Understanding the kinetics and directions of this continuing adaptation and its impact on viral fitness, immunogenicity and pathogenicity will be crucial to the successful design of effective HIV vaccines. Here we discuss some potential scenarios of viral and host coevolution.
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