[HTML][HTML] Activation of peroxisome proliferator-activated receptor-γ inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts

MJ Jeon, JA Kim, SH Kwon, SW Kim, KS Park… - Journal of Biological …, 2003 - ASBMB
Mesenchymal cells are able to differentiate into several distinct cell types, including
osteoblasts and adipocytes. The commitment to a particular lineage may be regulated by
specific transcription factors. Peroxisome proliferator-activated receptor-γ (PPARγ), acting in
conjunction with CCAAT/enhancer-binding protein-α, has been suggested as a key
regulator of adipogenic differentiation. Previous studies have shown that the activation of
PPARγ in osteoblasts suppresses osteoblast differentiation and the expression of …