Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis
A Pohl-Koppe, SK Burchett, EA Thiele… - Journal of …, 1998 - Elsevier
Acute disseminated encephalomyelitis (ADEM), a postinfectious illness of the central
nervous system (CNS), is thought to be an autoimmune disease. Here, we characterized the
cytokines secreted by myelin-reactive T cells generated from patients with ADEM. The
frequency of MBP-reactive T cell lines was ten-fold higher in patients with ADEM compared
to patients with encephalitis and normal subjects. Whereas there was no significant IFN-γ
secretion, the predominant cytokine secreted by MBP-reactive T cell lines was IL-4 in …
nervous system (CNS), is thought to be an autoimmune disease. Here, we characterized the
cytokines secreted by myelin-reactive T cells generated from patients with ADEM. The
frequency of MBP-reactive T cell lines was ten-fold higher in patients with ADEM compared
to patients with encephalitis and normal subjects. Whereas there was no significant IFN-γ
secretion, the predominant cytokine secreted by MBP-reactive T cell lines was IL-4 in …