[HTML][HTML] Lipoprotein lipase deficiency and CETP in streptozotocin-treated apoB-expressing mice
Y Kako, M Massé, LS Huang, AR Tall… - Journal of lipid …, 2002 - ASBMB
Both hyperglycemia and hyperlipidemia have been postulated to increase atherosclerosis in
patients with diabetes mellitus. To study the effects of diabetes on lipoprotein profiles and
atherosclerosis in a rodent model, we crossed mice that express human apolipoprotein B
(HuB), mice that have a heterozygous deletion of lipoprotein lipase (LPL1), and transgenic
mice expressing human cholesteryl ester transfer protein (CETP). Lipoprotein profiles due to
each genetic modification were assessed while mice were consuming a Western type diet …
patients with diabetes mellitus. To study the effects of diabetes on lipoprotein profiles and
atherosclerosis in a rodent model, we crossed mice that express human apolipoprotein B
(HuB), mice that have a heterozygous deletion of lipoprotein lipase (LPL1), and transgenic
mice expressing human cholesteryl ester transfer protein (CETP). Lipoprotein profiles due to
each genetic modification were assessed while mice were consuming a Western type diet …