[HTML][HTML] Stimulation of mitogen-activated protein kinase by G protein-coupled α2-adrenergic receptors does not require agonist-elicited endocytosis
NL Schramm, LE Limbird - Journal of Biological Chemistry, 1999 - ASBMB
Agonist-elicited receptor sequestration is strikingly different for the α 2A-versus α 2B-
adrenergic receptor (α 2-AR) subtypes; the α 2B-AR undergoes rapid and extensive
disappearance from the HEK 293 cell surface, whereas the α 2A-AR does not (Daunt, DA,
Hurt, C., Hein, L., Kallio, J., Feng, F., and Kobilka, BK (1997) Mol. Pharmacol. 51, 711–720;
Eason, MG, and Liggett, SB (1992) J. Biol. Chem. 267, 25473–25479). Since recent reports
suggest that endocytosis is required for some G protein-coupled receptors to stimulate the …
adrenergic receptor (α 2-AR) subtypes; the α 2B-AR undergoes rapid and extensive
disappearance from the HEK 293 cell surface, whereas the α 2A-AR does not (Daunt, DA,
Hurt, C., Hein, L., Kallio, J., Feng, F., and Kobilka, BK (1997) Mol. Pharmacol. 51, 711–720;
Eason, MG, and Liggett, SB (1992) J. Biol. Chem. 267, 25473–25479). Since recent reports
suggest that endocytosis is required for some G protein-coupled receptors to stimulate the …